Document 0052
 DOCN  M9490052
 TI    [Retroviral infection as a putative pathogen for sarcoidosis]
 DT    9411
 AU    Tamura N; Suzuki K; Iwase A; Yamamoto T; Kira S; Department of
       Respiratory Medicine, Juntendo University School of; Medicine.
 SO    Nippon Rinsho. 1994 Jun;52(6):1503-7. Unique Identifier : AIDSLINE
       MED/94322474
 AB    Sarcoidosis is a granulomatous disorder of unknown etiology. Accumulated
       data suggest that one or several exogenous or altered self antigens
       participate in producing pathophysiological change in sarcoidosis.
       Recently, analysis of retroviruses such as HTLV-1 and HIV-1 revealed
       that these viruses would produce autoimmune disease like symptoms
       including interstitial lung disease like pulmonary manifestation. We
       hypothesized novel type retrovirus or retrovirus related antigens might
       be a putative pathogen for sarcoidosis. Syncytial cell formation or
       cytopathic effect was observed in 6 of 24 patients (25%) after coculture
       of sarcoid BALF cells with U937 cells. Five of 18 culture supernatant
       showed moderate reverse transcriptase activity. Expression of clone 4-1
       env protein, one of the endogenous retroviral elements, was also
       observed in alveolar macrophages of sarcoidosis. These data encourages
       the further investigation of retrovirus as the pathogen of sarcoidosis.
 DE    Adult  Aged  Animal  Bronchoalveolar Lavage Fluid/MICROBIOLOGY  Cells,
       Cultured  English Abstract  Female  Human  Male  Middle Age
       Retroviridae/ISOLATION & PURIF  *Retroviridae Infections
       Sarcoidosis/*MICROBIOLOGY/PATHOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

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